Non-invasive Seizure Detection Using Wearable Wrist-worn Accelerometry and Deep Learning
Nilushika Udayangani Hewa Dehigahawattage, Kishor Nandakishor, Marimuthu Palaniswami
Abstract
Seizure monitoring and detection are crucial for reducing the morbidity and mortality associated with seizures. Current epilepsy care, often involving expensive video-electroencephalography (VEEG) monitoring, requires specialized expertise and is limited to in-hospital settings, and intrusive in nature. Seizure diaries, on the other hand, suffer from unreliability due to under-reporting, leading to incorrect therapeutic decisions. Wearable non-invasive seizure detection may offer a more tolerable and feasible solution for long-term ambulatory monitoring. This study explores a wearable remote monitoring system utilizing a single wrist-worn accelerometer device and capable of detecting multiple types of seizures, including shorter duration events. We enrolled 79 patients under video-electroencephalography monitoring to wear accelerometer devices and collect data. Concurrent VEEG recordings were reviewed by board-certified epileptologists to produce annotations, including seizure onset, offset, and seizure type. Using this data, we constructed a deep neural network based on the time-series ResNet architecture, which could discriminate among seizure and non-seizure events. Our proposed approach achieved a seizure detection sensitivity of 95.65% and an overall false alarm rate of 0.15/24 hours during the evaluation, which spanned 5576 hours of total recording. Additionally, it resulted in an area under the receiver operating characteristic curve (AUC-ROC) of 0.98 and an area under the precision-re call curve (AUC-PRC) of 0.67 when averaged over 20 patients who experienced 46 convulsive seizures. These promising results suggest that the proposed seizure detection system can be effectively used for long-term ambulatory seizure monitoring. Future steps include validating our findings in larger datasets and assessing the utility of detection for additional seizure types.