CFCH: Coarse-Fine Collaborative Hierarchical Learning for Anterior Segment Disease Analysis
Peng Wang, Haohan Zou, Yanlin Wu, Xueshuo Xie, Yan Wang, Tao Li
Abstract
Accurate classification of anterior segment diseases is crucial for ophthalmic screening and diagnosis. However, slit-lamp image analysis remains challenging due to substantial variability in imaging conditions and the intrinsic anatomical-disease hierarchy of ocular pathologies. Existing methods typically formulate this task as a flat multi-class classification problem, ignoring the structured dependency between anatomical regions (e.g., cornea, conjunctiva, and lens) and disease manifestations.To address these limitations, we propose CFCH, a Coarse-Fine Collaborative Hierarchical learning framework that explicitly models anatomical context and disease semantics through a dual-branch architecture. To enable effective cross-granularity collaboration, CFCH introduces semantic and cross-granularity attention consistency constraints, encouraging aligned yet complementary feature learning across branches. In addition, we construct AS-9K, a large-scale anterior segment dataset with 8975 images covering 12 common disease categories. To the best of our knowledge, AS-9K is the largest publicly available dataset for anterior segment image classification. Extensive experiments on two anterior segment datasets demonstrate that CFCH outperforms state-of-the-art methods. Qualitative visualizations further show more focused and lesion-relevant activation responses, validating the effectiveness of the proposed framework. Code will be available at https://github.com/ybupengwang/CFCH.